Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC2396291 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Li Ziyin Z Lee Ju Huck JH Chu Feixia F Burlingame Alma L AL Günzl Arthur A Wang Ching C CC
PloS one 20080611 6
Aurora B kinase is a key component of the chromosomal passenger complex (CPC), which regulates chromosome segregation and cytokinesis. An ortholog of Aurora B was characterized in Trypanosoma brucei (TbAUK1), but other conserved components of the complex have not been found. Here we identified four novel TbAUK1 associated proteins by tandem affinity purification and mass spectrometry. Among these four proteins, TbKIN-A and TbKIN-B are novel kinesin homologs, whereas TbCPC1 and TbCPC2 are hypothe ...[more]