Ontology highlight
ABSTRACT:
SUBMITTER: Rivera-Calzada A
PROVIDER: S-EPMC1796749 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Rivera-Calzada Angel A Spagnolo Laura L Pearl Laurence H LH Llorca Oscar O
EMBO reports 20061208 1
Recognition of DNA double-strand breaks during non-homologous end joining is carried out by the Ku70-Ku80 protein, a 150 kDa heterodimer that recruits the DNA repair kinase DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the lesion. The atomic structure of a truncated Ku70-Ku80 was determined; however, the subunit-specific carboxy-terminal domain of Ku80--essential for binding to DNA-PKcs--was determined only in isolation, and the C-terminal domain of Ku70 was not resolved in its DN ...[more]