Ontology highlight
ABSTRACT:
SUBMITTER: Reiling E
PROVIDER: S-EPMC3989187 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Reiling Erwin E Dollé Martijn E T ME Youssef Sameh A SA Lee Moonsook M Nagarajah Bhawani B Roodbergen Marianne M de With Piet P de Bruin Alain A Hoeijmakers Jan H JH Vijg Jan J van Steeg Harry H Hasty Paul P
PloS one 20140416 4
Ku80 and DNA-PKCS are both involved in the repair of double strand DNA breaks via the nonhomologous end joining (NHEJ) pathway. While ku80-/- mice exhibit a severely reduced lifespan and size, this phenotype is less pronounced in dna-pkcs-/- mice. However, these observations are based on independent studies with varying genetic backgrounds. Here, we generated ku80-/-, dna-pkcs-/- and double knock out mice in a C57Bl6/J*FVB F1 hybrid background and compared their lifespan, end of life pathology a ...[more]