Ontology highlight
ABSTRACT:
SUBMITTER: Cui T
PROVIDER: S-EPMC1796773 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
EMBO reports 20070112 2
Chromosomes in eukaryotes are linear, whereas those of most, but not all, prokaryotes are circular. To explore the effects of possessing a linear genome on prokaryotic cells, we linearized the Escherichia coli genome using the lysogenic lambda-like phage N15. Linear genome E. coli were viable and their genome structure was stable. There were no appreciable differences between cells with linear or circular genomes in growth rates, cell and nucleoid morphologies, genome-wide gene expression (with ...[more]