Caenorhabditis elegans as a model to determine fitness of antibiotic-resistant Salmonella enterica serovar typhimurium.
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ABSTRACT:
SUBMITTER: Paulander W
PROVIDER: S-EPMC1797747 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
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Caenorhabditis elegans as a model to determine fitness of antibiotic-resistant Salmonella enterica serovar typhimurium.
Paulander Wilhelm W Pennhag Alexandra A Andersson Dan I DI Maisnier-Patin Sophie S
Antimicrobial agents and chemotherapy 20061120 2
We used the ability of Salmonella enterica serovar Typhimurium to colonize the gut of Caenorhabditis elegans to measure the fitness costs imposed by antibiotic resistance mutations. The fitness costs determined in the nematode were similar to those measured in mice, validating its use as a simple host model to evaluate bacterial fitness. ...[more]
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