Ontology highlight
ABSTRACT:
SUBMITTER: Loovers HM
PROVIDER: S-EPMC1800594 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Loovers Harriët M HM Guinan Emma E Jones Gary W GW
Genetics 20061206 2
The Saccharomyces cerevisiae non-Mendelian genetic element [PSI+] is the prion form of the translation termination factor Sup35p. The ability of [PSI+] to propagate efficiently has been shown previously to depend upon the action of protein chaperones. In this article we describe a genetic screen that identifies an array of mutants within the two major cytosolic Hsp70 chaperones of yeast, Ssa1p and Ssa2p, which impair the propagation of [PSI+]. All but one of the mutants was located within the AT ...[more]