Ontology highlight
ABSTRACT:
SUBMITTER: Narayanan S
PROVIDER: S-EPMC170910 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
Narayanan Saravanakumar S Bösl Benjamin B Walter Stefan S Reif Bernd B
Proceedings of the National Academy of Sciences of the United States of America 20030722 16
The [PSI+] determinant of Saccharomyces cerevisiae, consisting of the cytosolic translation termination factor Sup35, is a prion-type genetic element that induces an inheritable conformational change and converts the Sup35 protein into amyloid fibers. The molecular chaperone Hsp104 is required to maintain self-replication of [PSI+]. We observe in vitro that addition of catalytic amounts of Hsp104 to the prion-determining region of the NM domain of Sup35, Sup355-26, results in the dissociation of ...[more]