Ontology highlight
ABSTRACT:
SUBMITTER: Kim A
PROVIDER: S-EPMC1800709 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Kim AeRi A Kiefer Christine M CM Dean Ann A
Molecular and cellular biology 20061211 4
The establishment of epigenetic marks, such as methylation on histone tails, is mechanistically linked to RNA polymerase II within active genes. To explore the interplay between these modifications in transcribed noncoding as well as coding sequences, we analyzed epigenetic modification and chromatin structure at high resolution across 300 kb of human chromosome 11, including the beta-globin locus which is extensively transcribed in intergenic regions. Monomethylated H3K4, K9, and K36 were broad ...[more]