COMIT: identification of noncoding motifs under selection in coding sequences.
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ABSTRACT:
SUBMITTER: Kural D
PROVIDER: S-EPMC3091326 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Publications
COMIT: identification of noncoding motifs under selection in coding sequences.
Kural Deniz D Ding Yang Y Wu Jiantao J Korpi Alicia M AM Chuang Jeffrey H JH
Genome biology 20091120 11
Coding nucleotide sequences contain myriad functions independent of their encoded protein sequences. We present the COMIT algorithm to detect functional noncoding motifs in coding regions using sequence conservation, explicitly separating nucleotide from amino acid effects. COMIT concurs with diverse experimental datasets, including splicing enhancers, silencers, replication motifs, and microRNA targets, and predicts many novel functional motifs. Intriguingly, COMIT scores are well-correlated to ...[more]
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