Ontology highlight
ABSTRACT:
SUBMITTER: Huppert JL
PROVIDER: S-EPMC1802602 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Huppert Julian L JL Balasubramanian Shankar S
Nucleic acids research 20061214 2
Certain G-rich DNA sequences readily form four-stranded structures called G-quadruplexes. These sequence motifs are located in telomeres as a repeated unit, and elsewhere in the genome, where their function is currently unknown. It has been proposed that G-quadruplexes may be directly involved in gene regulation at the level of transcription. In support of this hypothesis, we show that the promoter regions (1 kb upstream of the transcription start site TSS) of genes are significantly enriched in ...[more]