Adaptation of HIV-1 depends on the host-cell environment.
Ontology highlight
ABSTRACT:
SUBMITTER: van Opijnen T
PROVIDER: S-EPMC1803020 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Publications
Adaptation of HIV-1 depends on the host-cell environment.
van Opijnen Tim T de Ronde Anthony A Boerlijst Maarten C MC Berkhout Ben B
PloS one 20070307 3
Many viruses have the ability to rapidly develop resistance against antiviral drugs and escape from the host immune system. To which extent the host environment affects this adaptive potential of viruses is largely unknown. Here we show that for HIV-1, the host-cell environment is key to the adaptive potential of the virus. We performed a large-scale selection experiment with two HIV-1 strains in two different T-cell lines (MT4 and C8166). Over 110 days of culture, both virus strains adapted rap ...[more]
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