Ontology highlight
ABSTRACT:
SUBMITTER: Eugenin EA
PROVIDER: S-EPMC1805607 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Eugenin Eliseo A EA King Jessie E JE Nath Avindra A Calderon Tina M TM Zukin R Suzanne RS Bennett Michael V L MV Berman Joan W JW
Proceedings of the National Academy of Sciences of the United States of America 20070221 9
HIV infection of the central nervous system can result in neurologic dysfunction with devastating consequences in AIDS patients. NeuroAIDS is characterized by neuronal injury and loss, yet there is no evidence that HIV can infect neurons. Here we show that the HIV-encoded protein tat triggers formation of a macromolecular complex involving the low-density lipoprotein receptor-related protein (LRP), postsynaptic density protein-95 (PSD-95), N-methyl-d-aspartic acid (NMDA) receptors, and neuronal ...[more]