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Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons.

ABSTRACT: The membrane-associated guanylate kinase PSD-95 scaffolds N-methyl-d-aspartate receptors to cytoplasmic signaling molecules, and associates with other glutamate receptors at central synapses. However, regulation of PSD-95 in vivo is poorly understood. We provide evidence of an activity-dependent redistribution of PSD-95 to dendrites in central visual neurons that is tied to eye opening. Six hours after eye opening, increased dendritic PSD-95 coimmunoprecipitates with the same proportions of stargazin, increased proportions of the N-methyl-d-aspartate receptor subunit NR2A, and decreased proportions of NR2B. Sustained high levels of PSD-95 in dendrites are dependent on continued pattern vision in juvenile but not mature animals, suggesting that the stabilization of PSD-95 at synapses may be involved in the control of developmental plasticity.

SUBMITTER: Yoshii A

PROVIDER: S-EPMC298773 | biostudies-literature | 2003 Feb

REPOSITORIES: biostudies-literature

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Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons.

Yoshii Akira A Sheng Morgan H MH Constantine-Paton Martha M

Proceedings of the National Academy of Sciences of the United States of America 20030127 3

The membrane-associated guanylate kinase PSD-95 scaffolds N-methyl-d-aspartate receptors to cytoplasmic signaling molecules, and associates with other glutamate receptors at central synapses. However, regulation of PSD-95 in vivo is poorly understood. We provide evidence of an activity-dependent redistribution of PSD-95 to dendrites in central visual neurons that is tied to eye opening. Six hours after eye opening, increased dendritic PSD-95 coimmunoprecipitates with the same proportions of star ...[more]

PMID: 12552131

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