Ontology highlight
ABSTRACT:
SUBMITTER: Rowe M
PROVIDER: S-EPMC1805610 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Rowe Martin M Glaunsinger Britt B van Leeuwen Daphne D Zuo Jianmin J Sweetman David D Ganem Don D Middeldorp Jaap J Wiertz Emmanuel J H J EJ Ressing Maaike E ME
Proceedings of the National Academy of Sciences of the United States of America 20070221 9
Relatively little is known about immune evasion during the productive phase of infection by the gamma(1)-herpesvirus Epstein-Barr virus (EBV). The use of a unique system to isolate cells in lytic cycle allowed us to identify a host shutoff function operating in productively EBV-infected B cells. This impairment of protein synthesis results from mRNA degradation induced upon expression of the early lytic-cycle gene product BGLF5. Recently, a gamma(2)-herpesvirus, Kaposi sarcoma herpesvirus, has a ...[more]