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Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion.


ABSTRACT: Relatively little is known about immune evasion during the productive phase of infection by the gamma(1)-herpesvirus Epstein-Barr virus (EBV). The use of a unique system to isolate cells in lytic cycle allowed us to identify a host shutoff function operating in productively EBV-infected B cells. This impairment of protein synthesis results from mRNA degradation induced upon expression of the early lytic-cycle gene product BGLF5. Recently, a gamma(2)-herpesvirus, Kaposi sarcoma herpesvirus, has also been shown to encode a host shutoff function, indicating that host shutoff appears to be a general feature of gamma-herpesviruses. One of the consequences of host shutoff is a block in the synthesis of HLA class I and II molecules, reflected by reduced levels of these antigen-presenting complexes at the surface of cells in EBV lytic cycle. This effect could lead to escape from T cell recognition and elimination of EBV-producing cells, thereby allowing generation of viral progeny in the face of memory T cell responses.

SUBMITTER: Rowe M 

PROVIDER: S-EPMC1805610 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature

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Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion.

Rowe Martin M   Glaunsinger Britt B   van Leeuwen Daphne D   Zuo Jianmin J   Sweetman David D   Ganem Don D   Middeldorp Jaap J   Wiertz Emmanuel J H J EJ   Ressing Maaike E ME  

Proceedings of the National Academy of Sciences of the United States of America 20070221 9


Relatively little is known about immune evasion during the productive phase of infection by the gamma(1)-herpesvirus Epstein-Barr virus (EBV). The use of a unique system to isolate cells in lytic cycle allowed us to identify a host shutoff function operating in productively EBV-infected B cells. This impairment of protein synthesis results from mRNA degradation induced upon expression of the early lytic-cycle gene product BGLF5. Recently, a gamma(2)-herpesvirus, Kaposi sarcoma herpesvirus, has a  ...[more]

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