Ontology highlight
ABSTRACT:
SUBMITTER: Shu Y
PROVIDER: S-EPMC1821094 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Shu Yuuei Y Winfrey Sarah S Yang Zhi-Yong ZY Xu Ling L Rao Srinivas S SS Srivastava Indresh I Barnett Susan W SW Nabel Gary J GJ Mascola John R JR
Vaccine 20061107 8
DNA plasmids and recombinant adenovirus serotype-5 (rAd5) vectors are being studied in human clinical trials as HIV-1 vaccine candidates. Each elicits robust T-cell responses and modest antibody levels. Since protein immunization alone elicits antibody but not CD8 T-cell responses, we studied protein boosting of DNA and rAd5 HIV-1 vaccine vectors. A single Env protein immunization provided a marked boost in antibody titer in guinea pigs primed with either DNA or rAd5 vaccines, and the resulting ...[more]