Ontology highlight
ABSTRACT:
SUBMITTER: De Rosa SC
PROVIDER: S-EPMC3180898 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20110815 6
Many candidate HIV vaccines are designed to primarily elicit T cell responses. Although repeated immunization with the same vaccine boosts Ab responses, the benefit for T cell responses is ill defined. We compared two immunization regimens that include the same recombinant adenoviral serotype 5 (rAd5) boost. Repeated homologous rAd5 immunization fails to increase T cell responses, but increases gp140 Ab responses 10-fold. DNA prime, as compared with rAd5 prime, directs long-term memory CD8(+) T ...[more]