Ontology highlight
ABSTRACT:
SUBMITTER: Evans PA
PROVIDER: S-EPMC1821343 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
Evans P Andrew PA Cui Jian J Gharpure Santosh J SJ
Organic letters 20031001 21
[reaction: see text] The stereoselective intramolecular reductive etherification of delta-trialkylsilyloxy substituted ketones with catalytic bismuth tribromide and triethylsilane provides a convenient method for the construction of cis-2,6-disubstituted tetrahydropyrans. This method was highlighted in the key step of an expeditious total synthesis of the antibiotic, (-)-centrolobine. ...[more]