Ontology highlight
ABSTRACT:
SUBMITTER: Kramer P
PROVIDER: S-EPMC6772187 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20190807 37
A novel method for the highly stereoselective synthesis of tetrahydropyrans is reported. This domino reaction is based on a twofold addition of enamides to aldehydes followed by a subsequent cyclization and furnishes fully substituted tetrahydropyrans in high yields. Three new σ-bonds and five continuous stereogenic centers are formed in this one-pot process with a remarkable degree of diastereoselectivity. In most cases, the formation of only one out of 16 possible diastereomers is observed. Tw ...[more]