Ontology highlight
ABSTRACT:
SUBMITTER: Scobie HM
PROVIDER: S-EPMC1824706 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Scobie Heather M HM Marlett John M JM Rainey G Jonah A GJ Lacy D Borden DB Collier R John RJ Young John A T JA
PloS one 20070328 3
The anthrax toxin receptors, ANTXR1 and ANTXR2, act as molecular clamps to prevent the protective antigen (PA) toxin subunit from forming pores until exposure to low pH. PA forms pores at pH approximately 6.0 or below when it is bound to ANTXR1, but only at pH approximately 5.0 or below when it is bound to ANTXR2. Here, structure-based mutagenesis was used to identify non-conserved ANTXR2 residues responsible for this striking 1.0 pH unit difference in pH threshold. Residues conserved between AN ...[more]