Ontology highlight
ABSTRACT:
SUBMITTER: Pilpa RM
PROVIDER: S-EPMC3234216 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Pilpa Rosemarie M RM Bayrhuber Monika M Marlett John M JM Riek Roland R Young John A T JA
PLoS pathogens 20111208 12
Cellular receptors can act as molecular switches, regulating the sensitivity of microbial proteins to conformational changes that promote cellular entry. The activities of these receptor-based switches are only partially understood. In this paper, we sought to understand the mechanism that underlies the activity of the ANTXR2 anthrax toxin receptor-based switch that binds to domains 2 and 4 of the protective antigen (PA) toxin subunit. Receptor-binding restricts structural changes within the hep ...[more]