DTNBP1 genotype influences cognitive decline in schizophrenia.
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ABSTRACT:
SUBMITTER: Burdick KE
PROVIDER: S-EPMC1828039 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Publications
DTNBP1 genotype influences cognitive decline in schizophrenia.
Burdick Katherine E KE Goldberg Terry E TE Funke Birgit B Bates John A JA Lencz Todd T Kucherlapati Raju R Malhotra Anil K AK
Schizophrenia research 20061030 1-3
<h4>Objective</h4>Intellectual decline is common in schizophrenia and predicts functional outcome. While many patients undergo intellectual decline that typically predates the onset of symptoms, few studies have investigated the underlying mechanism through which this occurs. The current study assessed the relationship between intellectual decline in schizophrenia and genetic variation in dysbindin-1 (DTNBP1).<h4>Methods</h4>We assessed cognitive decline in 183 Caucasian patients with schizophre ...[more]
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