Ontology highlight
ABSTRACT:
SUBMITTER: Chen XW
PROVIDER: S-EPMC2396815 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
The Journal of cell biology 20080526 5
Schizophrenia is one of the most debilitating neuropsychiatric disorders, affecting 0.5-1.0% of the population worldwide. Its pathology, attributed to defects in synaptic transmission, remains elusive. The dystrobrevin-binding protein 1 (DTNBP1) gene, which encodes a coiled-coil protein, dysbindin, is a major susceptibility gene for schizophrenia. Our previous results have demonstrated that the sandy (sdy) mouse harbors a spontaneously occurring deletion in the DTNBP1 gene and expresses no dysbi ...[more]