Characterization of the rabbit HKalpha2 gene promoter.
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ABSTRACT:
SUBMITTER: Zies DL
PROVIDER: S-EPMC1828607 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Publications
Characterization of the rabbit HKalpha2 gene promoter.
Zies Deborah L DL Gumz Michelle L ML Wingo Charles S CS Cain Brian D BD
Biochimica et biophysica acta 20060912 10
The HKalpha2 gene directs synthesis of the HKalpha2 subunit of the H(+), K(+)-ATPase. In the kidney and colon, the gene is highly expressed and is thought to play a role in potassium (K(+)) conservation. The rabbit has been an important experimental system for physiological studies of ion transport in the kidney, so the rabbit HKalpha2 gene has been cloned and characterized. The genomic clones and the previously reported HKalpha2a and HKalpha2c subunit cDNAs provided a means to address several i ...[more]
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