Ontology highlight
ABSTRACT:
SUBMITTER: Chiba Y
PROVIDER: S-EPMC3486724 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Chiba Yoshihiko Y Goto Kumiko K Matsusue Kimihiko K Kimura Shioko S Misawa Miwa M
Journal of pharmacological sciences 20100320 4
RhoA upregulation has been suggested in bronchial smooth muscles (BSMs) of asthmatic rats. Here, we cloned/characterized the 5'-promoter region of the rat rhoA. A transcription-initiation site was identified at 66-bp upstream of the reference sequence, GenBank-BC061732. Luciferase assay using interleukin-13 (IL-13)-stimulated cells revealed a significant promoter activity at 238- to 166-bp upstream of the transcription-initiation site, which contains a signal transducer and activation of transcr ...[more]