Computational analysis of the synergy among multiple interacting genes.
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ABSTRACT:
SUBMITTER: Anastassiou D
PROVIDER: S-EPMC1828751 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Publications
Computational analysis of the synergy among multiple interacting genes.
Molecular systems biology 20070213
Diseases such as cancer are often related to collaborative effects involving interactions of multiple genes within complex pathways, or to combinations of multiple SNPs. To understand the structure of such mechanisms, it is helpful to analyze genes in terms of the purely cooperative, as opposed to independent, nature of their contributions towards a phenotype. Here, we present an information-theoretic analysis that provides a quantitative measure of the multivariate synergy and decomposes sets o ...[more]
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