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Defining genes: a computational framework.

ABSTRACT: The precise elucidation of the gene concept has become the subject of intense discussion in light of results from several, large high-throughput surveys of transcriptomes and proteomes. In previous work, we proposed an approach for constructing gene concepts that combines genomic heritability with elements of function. Here, we introduce a definition of the gene within a computational framework of cellular interactions. The definition seeks to satisfy the practical requirements imposed by annotation, capture logical aspects of regulation, and encompass the evolutionary property of homology.

SUBMITTER: Stadler PF

PROVIDER: S-EPMC2766041 | biostudies-other | 2009 Aug

REPOSITORIES: biostudies-other

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