Ontology highlight
ABSTRACT:
SUBMITTER: Gilbert RJ
PROVIDER: S-EPMC1832216 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Gilbert Robert J C RJ Gordiyenko Yulya Y von der Haar Tobias T Sonnen Andreas F-P AF Hofmann Gregor G Nardelli Maria M Stuart David I DI McCarthy John E G JE
Proceedings of the National Academy of Sciences of the United States of America 20070326 14
In the process of protein synthesis, the small (40S) subunit of the eukaryotic ribosome is recruited to the capped 5' end of the mRNA, from which point it scans along the 5' untranslated region in search of a start codon. However, the 40S subunit alone is not capable of functional association with cellular mRNA species; it has to be prepared for the recruitment and scanning steps by interactions with a group of eukaryotic initiation factors (eIFs). In budding yeast, an important subset of these ...[more]