Ontology highlight
ABSTRACT:
SUBMITTER: Tanay A
PROVIDER: S-EPMC1838490 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Tanay Amos A O'Donnell Anne H AH Damelin Marc M Bestor Timothy H TH
Proceedings of the National Academy of Sciences of the United States of America 20070321 13
Comparative genomics of CpG dinucleotides, which are targets of DNA methyltransferases in vertebrate genomes, has been constrained by their evolutionary instability and by the effect of methylation on their mutation rates. We compared the human and chimpanzee genomes to identify DNA sequence signatures correlated with rates of mutation at CpG dinucleotides. The new signatures were used to develop robust comparative genomics of CpG dinucleotides in heterogeneous regions and to identify genomic do ...[more]