Ontology highlight
ABSTRACT:
SUBMITTER: Orlando DA
PROVIDER: S-EPMC3483364 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Orlando David A DA Guenther Matthew G MG Frampton Garrett M GM Young Richard A RA
Genomics 20120720 5
TrxG and PcG complexes play key roles in the epigenetic regulation of development through H3K4me3 and H3K27me3 modification at specific sites throughout the human genome, but how these sites are selected is poorly understood. We find that in pluripotent cells, clustered CpG-islands at genes predict occupancy of H3K4me3 and H3K27me3, and these "bivalent" chromatin domains precisely span the boundaries of CpG-island clusters. These relationships are specific to pluripotent stem cells and are not r ...[more]