Ontology highlight
ABSTRACT:
SUBMITTER: Boehmerle W
PROVIDER: S-EPMC1838755 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Boehmerle Wolfgang W Splittgerber Ute U Lazarus Michael B MB McKenzie Kathleen M KM Johnston David G DG Austin David J DJ Ehrlich Barbara E BE
Proceedings of the National Academy of Sciences of the United States of America 20061117 48
Taxol (Paclitaxel) is an important natural product for the treatment of solid tumors. Despite a well documented tubulin-stabilizing effect, many side effects of taxol therapy cannot be explained by cytoskeletal mechanisms. In the present study submicromolar concentrations of taxol, mimicking concentrations found in patients, induced cytosolic calcium (Ca(2+)) oscillations in a human neuronal cell line. These oscillations were independent of extracellular and mitochondrial Ca(2+) but dependent on ...[more]