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RNA diversity has profound effects on the translation of neuronal nitric oxide synthase.

ABSTRACT: A comprehensive analysis of the structure of neuronal nitric oxide synthase (nNOS; EC 1.14.13.39) mRNA species revealed NOS1 to be the most structurally diverse human gene described to date in terms of promoter usage. Nine unique exon 1 variants are variously used for transcript initiation in diverse tissues, and each is expressed from a unique 5'-flanking region. The dependence on unique genomic regions to control transcription initiation in a cell-specific fashion burdens the transcripts with complex 5'-mRNA leader sequences. Elaborate splicing patterns that involve alternatively spliced leader exons and exon skipping have been superimposed on this diversity. Highly structured nNOS mRNA 5'-untranslated regions, which have profound effects on translation both in vitro and in cells, contain cis RNA elements that modulate translational efficiency in response to changes in cellular phenotype.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC18427 | biostudies-literature | 1999 Oct

REPOSITORIES: biostudies-literature

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RNA diversity has profound effects on the translation of neuronal nitric oxide synthase.

Wang Y Y   Newton D C DC   Robb G B GB   Kau C L CL   Miller T L TL   Cheung A H AH   Hall A V AV   VanDamme S S   Wilcox J N JN   Marsden P A PA  

Proceedings of the National Academy of Sciences of the United States of America 19991001 21

A comprehensive analysis of the structure of neuronal nitric oxide synthase (nNOS; EC 1.14.13.39) mRNA species revealed NOS1 to be the most structurally diverse human gene described to date in terms of promoter usage. Nine unique exon 1 variants are variously used for transcript initiation in diverse tissues, and each is expressed from a unique 5'-flanking region. The dependence on unique genomic regions to control transcription initiation in a cell-specific fashion burdens the transcripts with  ...[more]

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