Ontology highlight
ABSTRACT:
SUBMITTER: Achen MG
PROVIDER: S-EPMC18457 | biostudies-literature | 1998 Jan
REPOSITORIES: biostudies-literature
Achen M G MG Jeltsch M M Kukk E E Mäkinen T T Vitali A A Wilks A F AF Alitalo K K Stacker S A SA
Proceedings of the National Academy of Sciences of the United States of America 19980101 2
We have identified a member of the VEGF family by computer-based homology searching and have designated it VEGF-D. VEGF-D is most closely related to VEGF-C by virtue of the presence of N- and C-terminal extensions that are not found in other VEGF family members. In adult human tissues, VEGF-D mRNA is most abundant in heart, lung, skeletal muscle, colon, and small intestine. Analyses of VEGF-D receptor specificity revealed that VEGF-D is a ligand for both VEGF receptors (VEGFRs) VEGFR-2 (Flk1) an ...[more]