Ontology highlight
ABSTRACT:
SUBMITTER: Ruiz de Almodovar C
PROVIDER: S-EPMC3638787 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Neuron 20110601 5
Growing axons are guided to their targets by attractive and repulsive cues. In the developing spinal cord, Netrin-1 and Shh guide commissural axons toward the midline. However, the combined inhibition of their activity in commissural axon turning assays does not completely abrogate turning toward floor plate tissue, suggesting that additional guidance cues are present. Here we show that the prototypic angiogenic factor VEGF is secreted by the floor plate and is a chemoattractant for commissural ...[more]