Ontology highlight
ABSTRACT:
SUBMITTER: Zhang PJ
PROVIDER: S-EPMC1847652 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Zhang Pei-Jing PJ Zhao Jie J Li Hui-Yan HY Man Jiang-Hong JH He Kun K Zhou Tao T Pan Xin X Li Ai-Ling AL Gong Wei-Li WL Jin Bao-Feng BF Xia Qing Q Yu Ming M Shen Bei-Fen BF Zhang Xue-Min XM
The EMBO journal 20070308 7
Accumulated evidence indicates that progesterone receptors (PR) are involved in proliferation of breast cancer cells and are implicated in the development of breast cancer. In this paper, a yeast two-hybrid screen for PR led to the identification of CUE domain containing 2 (CUEDC2), whose function is unknown. Our results demonstrate that CUEDC2 interacts with PR and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. The inhibition of endogenous CUEDC2 by siRNA near ...[more]