Ontology highlight
ABSTRACT:
SUBMITTER: Ver Heul AM
PROVIDER: S-EPMC3591598 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Ver Heul Aaron M AM Fowler C Andrew CA Ramaswamy S S Piper Robert C RC
The Journal of biological chemistry 20130108 10
NOD1 and NOD2 (nucleotide-binding oligomerization domain-containing proteins) are intracellular pattern recognition receptors that activate inflammation and autophagy. These pathways rely on the caspase recruitment domains (CARDs) within the receptors, which serve as protein interaction platforms that coordinately regulate immune signaling. We show that NOD1 CARD binds ubiquitin (Ub), in addition to directly binding its downstream targets receptor-interacting protein kinase 2 (RIP2) and autophag ...[more]