Ontology highlight
ABSTRACT:
SUBMITTER: Irandoust MI
PROVIDER: S-EPMC1847666 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Irandoust Mahban I MI Aarts Lambertus H J LH Roovers Onno O Gits Judith J Erkeland Stefan J SJ Touw Ivo P IP
The EMBO journal 20070315 7
The hematopoietic system provides an attractive model for studying growth factor-controlled expansion and differentiation of cells in relation to receptor routing and its consequences for signal transduction. Suppressor of cytokine signaling (SOCS) proteins regulate receptor signaling partly via their ubiquitin ligase (E3)-recruiting SOCS box domain. Whether SOCS proteins affect signaling through modulating intracellular trafficking of receptors is unknown. Here, we show that a juxtamembrane lys ...[more]