Ontology highlight
ABSTRACT:
SUBMITTER: Emery B
PROVIDER: S-EPMC1472535 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Emery Ben B Cate Holly S HS Marriott Mark M Merson Tobias T Binder Michele D MD Snell Cameron C Soo Pik Ying PY Murray Simon S Croker Ben B Zhang Jian-Guo JG Alexander Warren S WS Cooper Helen H Butzkueven Helmut H Kilpatrick Trevor J TJ
Proceedings of the National Academy of Sciences of the United States of America 20060508 20
Enhancement of oligodendrocyte survival through activation of leukemia inhibitory factor receptor (LIFR) signaling is a candidate therapeutic strategy for demyelinating disease. However, in other cell types, LIFR signaling is under tight negative regulation by the intracellular protein suppressor of cytokine signaling 3 (SOCS3). We, therefore, postulated that deletion of the SOCS3 gene in oligodendrocytes would promote the beneficial effects of LIFR signaling in limiting demyelination. By studyi ...[more]