Ontology highlight
ABSTRACT:
SUBMITTER: Lebedev AA
PROVIDER: S-EPMC1847669 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Lebedev Andrey A AA Krause Margret H MH Isidro Anabela L AL Vagin Alexei A AA Orlova Elena V EV Turner Joanne J Dodson Eleanor J EJ Tavares Paulo P Antson Alfred A AA
The EMBO journal 20070315 7
Tailed bacteriophages and herpesviruses load their capsids with DNA through a tunnel formed by the portal protein assembly. Here we describe the X-ray structure of the bacteriophage SPP1 portal protein in its isolated 13-subunit form and the pseudoatomic structure of a 12-subunit assembly. The first defines the DNA-interacting segments (tunnel loops) that pack tightly against each other forming the most constricted part of the tunnel; the second shows that the functional dodecameric state must i ...[more]