Ontology highlight
ABSTRACT:
SUBMITTER: Brosey CA
PROVIDER: S-EPMC3575853 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Brosey Chris A CA Yan Chunli C Tsutakawa Susan E SE Heller William T WT Rambo Robert P RP Tainer John A JA Ivanov Ivaylo I Chazin Walter J WJ
Nucleic acids research 20130108 4
By coupling the protection and organization of single-stranded DNA (ssDNA) with recruitment and alignment of DNA processing factors, replication protein A (RPA) lies at the heart of dynamic multi-protein DNA processing machinery. Nevertheless, how RPA coordinates biochemical functions of its eight domains remains unknown. We examined the structural biochemistry of RPA's DNA-binding activity, combining small-angle X-ray and neutron scattering with all-atom molecular dynamics simulations to invest ...[more]