AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss.
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ABSTRACT:
SUBMITTER: Hsieh H
PROVIDER: S-EPMC1850952 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Publications
AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss.
Hsieh Helen H Boehm Jannic J Sato Chihiro C Iwatsubo Takeshi T Tomita Taisuke T Sisodia Sangram S Malinow Roberto R
Neuron 20061201 5
Beta amyloid (Abeta), a peptide generated from the amyloid precursor protein (APP) by neurons, is widely believed to underlie the pathophysiology of Alzheimer's disease. Recent studies indicate that this peptide can drive loss of surface AMPA and NMDA type glutamate receptors. We now show that Abeta employs signaling pathways of long-term depression (LTD) to drive endocytosis of synaptic AMPA receptors. Synaptic removal of AMPA receptors is necessary and sufficient to produce loss of dendritic s ...[more]
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