The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds.
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ABSTRACT:
SUBMITTER: Huang YJ
PROVIDER: S-EPMC1851090 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Publications
The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds.
Huang Yi-Jen YJ Maruyama Yutaka Y Dvoryanchikov Gennady G Pereira Elizabeth E Chaudhari Nirupa N Roper Stephen D SD
Proceedings of the National Academy of Sciences of the United States of America 20070326 15
ATP has been shown to be a taste bud afferent transmitter, but the cells responsible for, and the mechanism of, its release have not been identified. Using CHO cells expressing high-affinity neurotransmitter receptors as biosensors, we show that gustatory stimuli cause receptor cells to secrete ATP through pannexin 1 hemichannels in mouse taste buds. ATP further stimulates other taste cells to release a second transmitter, serotonin. These results provide a mechanism to link intracellular Ca(2+) ...[more]
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