Ontology highlight
ABSTRACT:
SUBMITTER: Cao G
PROVIDER: S-EPMC1851223 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
The American journal of pathology 20030401 4
Using LoxP/Cre technology, we generated a knockout mouse homozygous for a null mutation in exon 2 of Cav1. In male Cav1-/- animals, we observed a dramatic increase in the incidence of urinary calcium stone formation. In 5-month-old male mice, the incidence of early urinary calculi was 67% in Cav1-/- mice compared to 19% in Cav1+/+ animals. Frank stone formation was observed in 13% of Cav1-/- males but was not seen in Cav1+/+ mice. Urine calcium concentration was significantly higher in Cav1-/- m ...[more]