Caveolin 1 Promotes Renal Water and Salt Reabsorption.
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ABSTRACT:
SUBMITTER: Williere Y
PROVIDER: S-EPMC5765123 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
Caveolin 1 Promotes Renal Water and Salt Reabsorption.
Willière Yan Y Borschewski Aljona A Patzak Andreas A Nikitina Tatiana T Dittmayer Carsten C Daigeler Anna L AL Schuelke Markus M Bachmann Sebastian S Mutig Kerim K
Scientific reports 20180111 1
Caveolin-1 (Cav1) is essential for the formation of caveolae. Little is known about their functional role in the kidney. We tested the hypothesis that caveolae modulate renal salt and water reabsorption. Wild-type (WT) and Cav1-deficient (Cav1-/-) mice were studied. Cav1 expression and caveolae formation were present in vascular cells, late distal convoluted tubule and principal connecting tubule and collecting duct cells of WT but not Cav1-/- kidneys. Urinary sodium excretion was increased by 9 ...[more]
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