Ontology highlight
ABSTRACT:
SUBMITTER: Seibl R
PROVIDER: S-EPMC1851232 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
Seibl Reinhart R Birchler Thomas T Loeliger Susanne S Hossle Johann Peter JP Gay Renate E RE Saurenmann Traudl T Michel Beat A BA Seger Reinhard A RA Gay Steffen S Lauener Roger P RP
The American journal of pathology 20030401 4
Toll-like receptors (TLRs) are involved in mediating cell activation on stimulation with microbial constituents. We investigated the role for TLRs in synovial fibroblast (SF) activation in rheumatoid arthritis (RA). We analyzed whether stimulation with interleukin-1 beta and tumor necrosis factor-alpha, cytokines present in RA synovium, influences expression of TLR genes in SFs. The effects were compared with those of treatment with lipopolysaccharide and a synthetic lipopeptide (sBLP). Gene exp ...[more]