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Orthogonal sulfation strategy for synthetic heparan sulfate ligands.

ABSTRACT: [reaction: see text] An orthogonal sulfation strategy involving six different protecting groups has been developed for generating sulfated carbohydrate libraries based on heparan. Chemoselective cleavage conditions (optimized for a heparan disaccharide) can be performed in the presence of sulfate esters as well as the remaining protecting groups.

SUBMITTER: Fan RH 

PROVIDER: S-EPMC1851889 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature

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Orthogonal sulfation strategy for synthetic heparan sulfate ligands.

Fan Ren-Hua RH   Achkar Jihane J   Hernández-Torres Jesús M JM   Wei Alexander A  

Organic letters 20051001 22

[reaction: see text] An orthogonal sulfation strategy involving six different protecting groups has been developed for generating sulfated carbohydrate libraries based on heparan. Chemoselective cleavage conditions (optimized for a heparan disaccharide) can be performed in the presence of sulfate esters as well as the remaining protecting groups. ...[more]

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