Orthogonal sulfation strategy for synthetic heparan sulfate ligands.
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ABSTRACT:
SUBMITTER: Fan RH
PROVIDER: S-EPMC1851889 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Publications
Orthogonal sulfation strategy for synthetic heparan sulfate ligands.
Fan Ren-Hua RH Achkar Jihane J Hernández-Torres Jesús M JM Wei Alexander A
Organic letters 20051001 22
[reaction: see text] An orthogonal sulfation strategy involving six different protecting groups has been developed for generating sulfated carbohydrate libraries based on heparan. Chemoselective cleavage conditions (optimized for a heparan disaccharide) can be performed in the presence of sulfate esters as well as the remaining protecting groups. ...[more]
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