Expression of IL-1beta in supraspinal brain regions in rats with neuropathic pain.
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ABSTRACT:
SUBMITTER: Apkarian AV
PROVIDER: S-EPMC1851944 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
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Expression of IL-1beta in supraspinal brain regions in rats with neuropathic pain.
Apkarian A Vania AV Lavarello Simona S Randolf Anke A Berra Hector H HH Chialvo Dante R DR Besedovsky Hugo O HO del Rey Adriana A
Neuroscience letters 20060914 2
We examined mRNA expression of the pro-inflammatory cytokine IL-1beta in the brainstem, thalamus, and prefrontal cortex in two rat models of neuropathic pain. Rats received a neuropathic injury: spared nerve injury (SNI) or chronic constriction injury (CCI), sham injury, or were minimally handled (control). Neuropathic pain-like behavior was monitored by tracking tactile thresholds. SNI-injured animals showed a robust decrease in tactile thresholds of the injured foot, while CCI-injured animals ...[more]
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