Ontology highlight
ABSTRACT:
SUBMITTER: Harris J
PROVIDER: S-EPMC3058966 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Harris James J Hartman Michelle M Roche Caitrionna C Zeng Shijuan G SG O'Shea Amy A Sharp Fiona A FA Lambe Eimear M EM Creagh Emma M EM Golenbock Douglas T DT Tschopp Jurg J Kornfeld Hardy H Fitzgerald Katherine A KA Lavelle Ed C EC
The Journal of biological chemistry 20110112 11
Autophagy is a key regulator of cellular homeostasis that can be activated by pathogen-associated molecules and recently has been shown to influence IL-1β secretion by macrophages. However, the mechanisms behind this are unclear. Here, we describe a novel role for autophagy in regulating the production of IL-1β in antigen-presenting cells. After treatment of macrophages with Toll-like receptor ligands, pro-IL-1β was specifically sequestered into autophagosomes, whereas further activation of auto ...[more]