Clustering of phosphorylation site recognition motifs can be exploited to predict the targets of cyclin-dependent kinase.
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ABSTRACT:
SUBMITTER: Moses AM
PROVIDER: S-EPMC1852407 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
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Clustering of phosphorylation site recognition motifs can be exploited to predict the targets of cyclin-dependent kinase.
Moses Alan M AM Hériché Jean-Karim JK Durbin Richard R
Genome biology 20070101 2
Protein kinases are critical to cellular signalling and post-translational gene regulation, but their biological substrates are difficult to identify. We show that cyclin-dependent kinase (CDK) consensus motifs are frequently clustered in CDK substrate proteins. Based on this, we introduce a new computational strategy to predict the targets of CDKs and use it to identify new biologically interesting candidates. Our data suggest that regulatory modules may exist in protein sequence as clusters of ...[more]
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