Ontology highlight
ABSTRACT:
SUBMITTER: Moza B
PROVIDER: S-EPMC1852840 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Moza Beenu B Varma Ashok K AK Buonpane Rebecca A RA Zhu Penny P Herfst Christine A CA Nicholson Melissa J MJ Wilbuer Anne-Kathrin AK Seth Nilufer P NP Wucherpfennig Kai W KW McCormick John K JK Kranz David M DM Sundberg Eric J EJ
The EMBO journal 20070201 4
Superantigens (SAGs) bind simultaneously to major histocompatibility complex (MHC) and T-cell receptor (TCR) molecules, resulting in the massive release of inflammatory cytokines that can lead to toxic shock syndrome (TSS) and death. A major causative agent of TSS is toxic shock syndrome toxin-1 (TSST-1), which is unique relative to other bacterial SAGs owing to its structural divergence and its stringent TCR specificity. Here, we report the crystal structure of TSST-1 in complex with an affinit ...[more]