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Beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1.


ABSTRACT: The human gene Teratocarcinoma-derived growth factor 1 (TDGF1)/Cripto-1/CR-1 which is expressed in a wide variety of human carcinomas is a member of the EGF-cripto FRL1 cryptic (EGF-CFC) gene family. A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/beta-catenin/TCF signaling pathway, also express CR-1. Expression of a short form of CR-1 mRNA in colon carcinoma and hepatoma cell lines suggests that there may be differential regulation of CR-1 expression by the canonical Wnt signaling pathway in colon cancer as well as hepatoma cell lines. The present study demonstrates a direct transcriptional regulation of the short form CR-1 expression by the canonical Wnt signaling pathway through an intronic-exonic enhancer element, containing three tandem TCF/LEF binding sites within the CR-1 gene.

SUBMITTER: Hamada S 

PROVIDER: S-EPMC1853279 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature

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beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1.

Hamada Shin S   Watanabe Kazuhide K   Hirota Morihisa M   Bianco Caterina C   Strizzi Luigi L   Mancino Mario M   Gonzales Monica M   Salomon David S DS  

Biochemical and biophysical research communications 20070202 1


The human gene Teratocarcinoma-derived growth factor 1 (TDGF1)/Cripto-1/CR-1 which is expressed in a wide variety of human carcinomas is a member of the EGF-cripto FRL1 cryptic (EGF-CFC) gene family. A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/beta-catenin/TCF signaling pathway, also express CR-1. Expression of a short form of CR-1 mRNA in colon carcinoma and hepatoma cell lines suggests that there may be differential regulation  ...[more]

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