Ontology highlight
ABSTRACT:
SUBMITTER: Hamada S
PROVIDER: S-EPMC1853279 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Hamada Shin S Watanabe Kazuhide K Hirota Morihisa M Bianco Caterina C Strizzi Luigi L Mancino Mario M Gonzales Monica M Salomon David S DS
Biochemical and biophysical research communications 20070202 1
The human gene Teratocarcinoma-derived growth factor 1 (TDGF1)/Cripto-1/CR-1 which is expressed in a wide variety of human carcinomas is a member of the EGF-cripto FRL1 cryptic (EGF-CFC) gene family. A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/beta-catenin/TCF signaling pathway, also express CR-1. Expression of a short form of CR-1 mRNA in colon carcinoma and hepatoma cell lines suggests that there may be differential regulation ...[more]